Abstract
AbstractA Pd‐catalyzed cascade reaction of terminal alkynes with allylic halides to afford stereodefined skipped trienes was developed. The methodology leads to efficient construction of a series of stereodefined skipped trienes under mild reaction conditions in a single‐step without organometallic alkyne. Preliminary mechanism investigations indicated that the Sonogashira reaction and the radical pathway might not be involved in this novel multicomponent coupling reaction.
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