Abstract
Coronary heart disease (CHD) is highly prevalent globally and a major cause of mortality. Genetic predisposition is a non-modifiable risk factor associated with CHD. Eighty-four Chinese patients with CHD and 253 healthy Chinese controls without CHD were recruited. Major clinical data were collected, and a single nucleotide polymorphism (SNP) in the stromal cell-derived factor 1 (SDF-1) gene at position 801 (G to A, rs1801157) in the 3'-untranslated region was identified. The correlation between rs1801157 genotypes and CHD was evaluated by a multivariate logistic regression analysis. The allele frequency in the CHD and control groups was in Hardy-Weinberg equilibrium (HWE) (p > 0.05). The frequency of the GG genotype in the CHD group (59.5%) was significantly higher than that in the control group (49.8%) (p = 0.036). A number of variables, including male sex, age, presence of hypertension, and the levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), uric acid, and total bilirubin, were associated with CHD in a primary univariate analysis. In a multivariable logistic regression analysis, the GG genotype (GG:AA, odds ratio (OR) = 2.31, 95% confidence interval (CI) = 1.21–5.23), male sex, advanced age (≥60 years), presence of hypertension, LDL-C level ≥ 3.33 mg/dL, HDL-C level < 1.03 mg/dL, and TG level ≥ 1.7 mg/dL were independent risk factors for CHD.
Highlights
Coronary heart disease (CHD) is caused by obstruction of epicardial coronary artery that supplies blood and oxygen to the heart [1]
The proportion of males and presence of hypertension were significantly greater in the CHD group than in the control group
Among the genetic factors associated with disease, single nucleotide polymorphism (SNP) have a major influence on individual susceptibility to various diseases [20]
Summary
Coronary heart disease (CHD) is caused by obstruction of epicardial coronary artery that supplies blood and oxygen to the heart [1]. The narrowing of these small arteries originates from plaque buildup in the coronary arteries—a condition called atherosclerosis [1]. Plaques release chemicals that make the inner walls of blood vessels sticky [3]. This can aggravate atherosclerosis by causing various substances, including inflammatory cells, lipoproteins, and calcium, in the bloodstream to stick to the inside of the vessel wall [1,2,3]. CHD is a major health threat to people around the world [1,2,3]
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