A Single Institution Study Experience of Secondary Breast Angiosarcoma after Breast Conserving Treatment: Multidisciplinary Management

Strazzanti Angela,Gangi Santi,Trovato Claudio,Spatola Corrado,Milazzotto Roberto,Marletta Dario

doi:10.23937/2378-3419/1410114

Strazzanti Angela, Gangi Santi + Show 4 more

Open Access

https://doi.org/10.23937/2378-3419/1410114

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Abstract

A Single Institution Study Experience of Secondary Breast Angiosarcoma after Breast Conserving Treatment: Multidisciplinary Management

Highlights

In this work diagnosis, management, and outcome of RIAS in a small number of patients with breast cancer are being discussed.As a very rare vascular tumor, breast angiosarcoma (AS) can be divided into primary, if it arises without a known precursor, or secondary, if it occurs at the site of previously irradiated skin, in which case it is known as a Radiation-Induced Angiosarcoma (RIAS) of the breast [1]
No positive margins were reported in the patients who had received radical mastectomy performed by the same surgical team
Numerous studies have suggested the correlation between the onset of soft tissue sarcomas and the radiation treatments performed to deal with breast tumors

Summary

Introduction

Management, and outcome of RIAS in a small number of patients with breast cancer are being discussed.As a very rare vascular tumor, breast angiosarcoma (AS) can be divided into primary, if it arises without a known precursor, or secondary, if it occurs at the site of previously irradiated skin, in which case it is known as a Radiation-Induced Angiosarcoma (RIAS) of the breast [1]. Management, and outcome of RIAS in a small number of patients with breast cancer are being discussed. Still, no evidence-based guidelines concerning the ideal treatment of angiosarcomas exist. In those patients undergoing breast conserving surgery with adjuvant radiotherapy, the estimated incidence of RIAS varies between 0.05 and 0.3%, accounting for less than 1% of breast tumors [1,2,3,4] and for approximately about 3% of all soft-tissue sarcomas. The incidence of RIAS appears to be increasing, perhaps reflecting the long latency period for the development of these tumours following the widespread adoption of adjuvant radiotherapy for breast cancer

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Conclusion