A single institution analysis of recurrence in myxoid liposarcoma

Abstract

Background: Myxoid liposarcomas account for approximately one third of all liposarcomas and typically present as a slow-growing, deep-seated tumor in the lower extremity. Although approximately one-third of patients develop metastases and eventually die from their tumors, prognostic factors for recurrence have not been thoroughly studied. The effects of radiotherapy and perioperative allogeneic blood transfusions on tumor recurrence in primary myxoid liposarcomas were investigated. Patients and Methods: A retrospective review of 47 primary myxoid liposarcomas treated at a single institution was completed. Morphologic diagnoses were confirmed by soft tissue pathologists without prior knowledge of the clinical features, treatment, or outcome. Associations among treatment factors and recurrence were examined. Results: Four (9%) and fourteen (30%) patients developed local recurrences and distant metastases, respectively. The median follow-up time was 54 months. There were no local recurrences among those who received radiotherapy, thus producing a significant decrease in local recurrence in those patients who received radiotherapy ( p [Cox model]=0.010). The receipt of ≥3 blood transfusions correlated with an increase in tumor local recurrence ( p [Cox model]=0.030). Conclusions: Radiotherapy and perioperative blood transfusion quantity may have an effect on tumor recurrence and warrant further investigation. Mini -Abstract: Radiotherapy and perioperative blood transfusion quantity have a significant effect on myxoid liposarcoma recurrence.