Abstract
This study assessed treatment outcomes of Helicobacter pylori (Hpylori) infection among inner-city children. This was a retrospective study of patients aged 1-21years who underwent initial treatment for Hpylori infection from 2011 to 2015. We included patients who completed 2weeks of treatment with documented adequate compliance after Hpylori infection was diagnosed. Treatment outcomes were measured based on stool Hpylori antigen and/or histology. Of the total 261 patients diagnosed with Hpylori, 239 completed the first-line treatment. The regimens used included amoxicillin/clarithromycin/proton pump inhibitor (PPI) in 207/239 patients (86.6%), amoxicillin/metronidazole/PPI in 14/239 patients (5.8%) and other regimens in 18/239 patients (7.5%). Hpylori eradication status was tested in 111/207 (53.6%) patients treated with amoxicillin/clarithromycin/PPI, and the eradication was achieved in 84/111(75.7%) patients. The treatment success rates for amoxicillin/metronidazole/PPI and other regimens were 71.4% (5/7) and 63.6% (7/11), respectively. There was no statistical significance of post-treatment stool Hpylori antigen results between PPI (n=31) and no PPI (n=43) users. The study showed an eradication rate of 75.7% with the regimen amoxicillin/clarithromycin/PPI suggesting significant antibiotic resistance in our population. The use of PPI did not influence post-treatment stool Hpylori antigen results.
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