A single center retrospective study on hospitalization information for 812 cases of very low birth weight and extremely low birth weight infants

Abstract

Objective To analyze the survival rate and hospitalization information for 812 cases of very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. Methods The retrospective study was conducted in a single center, Department of Neonatology, Hubei Women and Children Hospital, from January 2009 to December 2014, where the data of 812 infants with birth weight(BW) less than 1 500 g was analyzed in regard to perinatal condition, treatment and complications of these in relation to prognosis. Results (1)A total of 621 cases(76.5%) had favorable prognosis.(2)There was a significant difference in the favorable prognosis rate between different BW groups (χ2=28.87, P<0.05) and different gestational age(GA) groups (χ2=14.77, P<0.05). The favorable prognosis rate for the male infants(χ2=4.69, P<0.05), puerpera age between 17-25 and 36-46 years old (χ2=11.19, P<0.05), usage of prenatal hormones(χ2=8.02, P<0.05), the infants without intrauterine infection (χ2=8.61, P<0.05), the mother without gestational hypertension (χ2=7.20, P<0.05) and gestational diabetes mellitus(χ2=19.2, P<0.05) were different compared to the control groups.(3)Infants with peripherally inserted central catheter (PICC) (χ2=33.31, P<0.05)and recovery birth weight within 10 days(χ2=29.65, P<0.05) had higher favorable prognosis rate compared to the control groups, which had significant differences.(4)Infants with intraventricular haemorrhage (IVH)(χ2=13.16, P<0.05), respiratory distress syndrome (RDS)(χ2=7.59, P<0.05), necrotizing enterocolitis (NEC)(χ2=13.02, P<0.05) and serious asphyxia (χ2=6.05, P<0.05)had lower favorable prognosis rates than those did not, with significant differences.(5)Logistic analysis: the lower BW, smaller GA, earlier birth, unused PICC, serious asphyxia, IVH, RDS were risk factors for poor prognosis(all P<0.05). Conclusions The favorable prognosis rate of VLBW and ELBW infants has improved gradually, and is closely related to GA, BW, maternal age, perinatal care, prevention complication, treatment of disease and social factors etc. Key words: Very low birth weight infant; Extremely low birth weight infant; Favorable prognosis rate; Treatment information; Single center study