A single bout of eccentric exercise results in a type II muscle fiber specific increase in satellite cell content and activation status

Abstract

Introduction: Satellite cells (SCs) are instrumental for repair, regeneration and growth of human skeletal muscle tissue. Following a single bout of exercise skeletal muscle SC can activate, proliferate and differentiate to form new SCs. In accordance, increases in mixed muscle SC content have been reported after 24–48h of recovery from a single bout of exercise. So far, little data exists on the fiber type-specific changes in SC content and activation status during post-exercise recovery. The present study investigates the impact of a single bout of eccentric exercise on skeletal muscle fiber type specific SC content and activation status following 24h of post-exercise recovery.