Abstract
Background and Aim: Irritable bowel syndrome (IBS) is a common medical disorder that may be severe enough to impair the quality of life. This study aimed to assess the role of each of dietary, psychiatric, autonomic, and microbiology background and their interactions in Egyptian patients with IBS. Patients and Methods: Forty adult patients diagnosed with IBS, equally divided into 2 groups the diarrhea predominant and the constipation predominant, were recruited from the Endoscopy Unit. Dietary assessment was done by monthly food frequency questionnaire. Psychiatric assessment was done by both the Eysenck Personality Questionnaire (EPQ) and Hopkins Symptom Checklist (HSCL-90). Microbiologic evaluation was done by faecal cultures and neurophysiologic autonomic evaluation was done via the sympathetic skin response and the parasympathetic R-R interval variation. Another 20 healthy subjects were included as control group. Results: All IBS patients were young, with significant female predominance (P = 0.007), particularly in IBS-C group (20/20; 100%, P = 0.003). Psychologically, abnormal scores of neuroticism, extraversion and criminality, and depression, obsessive compulsion, somatization, sensitivity and anxiety in both IBS groups with particularly extraversion, criminality and depression were significantly higher in constipation subtype. Microbiologically, Bacteroids were significantly related to IBS, while Klebsiella was significantly deficient without significant difference between its groups. On the contrary, neither diet nor autonomic activity showed any significant relation. Conclusions: IBS is a disorder induced by many factors and affected by several interacting agents, thus revealing controversial results when studied simultaneously.
Highlights
Irritable bowel syndrome (IBS) is a common functional intestinal disorder constituting a major health complaint and is the most commonly diagnosed gut disease [1].Pathogenesis of IBS is multifactorial: dietary, microbiologic, and neurophysiologic [2].Patients may correlate ingestion of certain foods with their IBS complaints [1]
Bacteroids were significantly related to IBS, while Klebsiella was significantly deficient without significant difference between its groups
This study included 40 adult patients who attended the colonoscopy room of the Gastrointestinal Endoscopy Unit at Kasr El-Ainy Hospital, Faculty of Medicine, Cairo University. They were diagnosed to have IBS according to Rome III criteria
Summary
Irritable bowel syndrome (IBS) is a common functional intestinal disorder constituting a major health complaint and is the most commonly diagnosed gut disease [1].Pathogenesis of IBS is multifactorial: dietary (food sensitivity and carbohydrate malabsorption), microbiologic (altered fecal microbiota, bacterial overgrowth, and post infectious reactivity), and neurophysiologic (brain-gut interaction, altered gut motility, visceral hypersensitivity, intestinal inflammation) [2].Patients may correlate ingestion of certain foods with their IBS complaints [1]. Irritable bowel syndrome (IBS) is a common functional intestinal disorder constituting a major health complaint and is the most commonly diagnosed gut disease [1]. Pathogenesis of IBS is multifactorial: dietary (food sensitivity and carbohydrate malabsorption), microbiologic (altered fecal microbiota, bacterial overgrowth, and post infectious reactivity), and neurophysiologic (brain-gut interaction, altered gut motility, visceral hypersensitivity, intestinal inflammation) [2]. This study aimed to assess the role of each of dietary, psychiatric, autonomic, and microbiology background and their interactions in Egyptian patients with IBS. Microbiologic evaluation was done by faecal cultures and neurophysiologic autonomic evaluation was done via the sympathetic skin response and the parasympathetic R-R interval variation. Another 20 healthy subjects were included as control group.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
