Abstract
The influence of integral or volume dose upon the response of the patient was recognized empirically shortly after the first use of ionizing radiation for the treatment of human illness. Beclere in 1915 noted that large-field irradiation is less well tolerated than that limited to small areas or volumes (1). Integral dose alone is certainly not sufficient to predict lethality, radiation illness, hematopoietic depression, or local reaction. The tissue irradiated, the size of the subject, and the protection of hematopoietic tissue are among the many variables shown to influence response (2-4). Recognizing these limitations, it is nevertheless likely that a useful correlation between integral dose and patient response for many treatment conditions may be obtained. For such clinical correlation to become routine, there must be a simple and reasonably accurate technic for calculating integral dose with each treatment planning. Mayneord and his associates (5-7) initiated a formal and quantitative approach to th...
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