A simpler and greener protocol for the preparation of β-acetylamino ketones by a one-pot reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile in the presence of zeolite Hβ as a reusable catalyst

Ramakrishna P Bhat,Vivek P Raje,Varughese M Alexander,Sachin B Patil,Shriniwas D Samant

doi:10.1016/j.tetlet.2005.05.018

A simpler and greener protocol for the preparation of β-acetylamino ketones by a one-pot reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile in the presence of zeolite Hβ as a reusable catalyst

Ramakrishna P Bhat, Vivek P Raje + Show 3 more

https://doi.org/10.1016/j.tetlet.2005.05.018

Copy DOI

Journal: Tetrahedron Letters	Publication Date: May 26, 2005
Citations: 23

Affiliation: Institute of Chemical Technology

#One-pot Reaction Of Aryl Aldehydes #Enolisable Ketone + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

β-Acetylamino ketones have been obtained in a one-pot coupling of an aldehyde with an enolisable ketone, acetyl chloride and acetonitrile in the presence of zeolite Hβ as catalyst at room temperature (26–28 °C). The procedure has the advantages of mild workup, circumvention of high temperature and inert atmosphere. The catalyst was found to be recyclable.

Full Text