A simple way to novel 2‐dichloromethyl‐5‐aryl‐2H‐tetrazoles

Abstract

AbstractA series of 2‐dichloromethyl‐5‐aryl‐2H‐tetrazoles (3a–i) were synthesized by the reaction of 5‐aryl‐NH‐tetrazoles with trichloromethane in strong organic basic condition. The reaction represents a single‐stage access to a new class of promising compounds, which not only can have biological activity, but can also serve as intermediates for further alkylation of halogen and the introduction of various fragments into the structure. The compounds obtained were fully characterized by means of ESI–MS, 1H and 13C{1H} NMR spectroscopies, as well as by single‐crystal X‐ray diffraction (for 3b) the structural parameters as well as the vibrational corrections to enthalpies and total energies of the investigated systems were calculated using DFT B3LYP/6‐31+G** approach.