Abstract
This paper describes the development and characterization of a hydrazone-type chemosensor for the detection of Al3+ ions. Hydrazone is based on pyridoxal 5′-phosphate and pyrazine-2-carbohydrazide and exhibits a blue emissive turn-on response upon binding to Al3+. The aggregation-induced emission enhancement phenomenon of the sensor and its Al3+ complex was investigated in mixed DMSO/H2O solvents. The sensor is capable of detecting extremely low levels of Al3+ ions (8 nM) in almost pure water, making it suitable for analyzing water with good ion recovery. Quantum chemical calculations were used to optimize the structure and electron absorption spectra of the sensor and its Al complex. The chemosensor has low toxicity levels (up to 50 μM) on tumor and non-tumor cell lines, which makes it a potential candidate for bioimaging use. This study provides valuable insights into the development of fluorescence sensors for precise recognition of metal ions.
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