Abstract
Because acrylic acid is a volatile organic compound, the precise quantification of acrylic acid by thin-layer chromatography (TLC) analysis is difficult. Herein, we report a simple TLC–densitometric method for the quantification of acrylic acid in aqueous solutions following a labeling procedure using the Mizoroki-Heck coupling reaction. To make acrylic acid nonvolatile and highly sensitive for ultraviolet (UV) detection, acrylic acid in an aqueous solution was reacted with iodobenzene in a dimethyl sulfoxide solution using a base (potassium carbonate) and a catalyst (FibreCat 1001), affording trans-cinnamic acid. High-performance liquid chromatography (HPLC) analysis showed that acrylic acid could be labeled over a range of 0.01–10 mM at 60°C for 30 min and the average reaction yield was 96.0%. To quantify acrylic acid by TLC analysis, the reaction mixture was extracted using ethyl acetate and then spotted on a silica gel 60 F254 TLC plate. The spots corresponding to the labeled acrylic acid over a range...
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