Abstract
A straightforward synthetic route to newN‐heterocyclic carbene (NHC)‐gold‐steroidyl complexes is reported. The desired complexes were obtained using a weak base (such as K2CO3) through a concerted‐metallation‐deprotonation (CMD) reaction mechanism occurring between [Au(NHC)Cl] and ethisterone as a model steroid‐based alkyne. Most complexes displayed good cytotoxicity against a panel of cancer cell lines with IC50values in the low micromolar range. Cellular uptake of the most active complex2ainto MCF‐7 breast cancer cells was facilitated by the coordinated ethisterone ligand.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
