Abstract
A general approach is outlined here for the synthesis of hydroxyethylene dipeptide isostere ( 1) starting from D-glucose which can be employed to introduce any group at P 1 or P 1, positions of such isosteres. A highly stereoselective synthesis of ( 2R,4 S,5S)- N-Boc- O-benzyl-5-amino4-hydroxy-2-methyl-6-phenylhexanoic acid methyl ester ( 2) is accomplished based on this strategy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
