Abstract
A simple, rapid and sensitive spectrophotometric method for the determination of captopril (CPT) in pharmaceutical formulations is proposed. This method is based on the reduction reaction of ammonium molybdate, in the presence of sulphuric acid, for the group thiol of CPT, producing a green compound (λ max 407 nm). Beer's law is obeyed in a concentration range of 4.60 x 10-4 - 1.84 x 10-3 mol l-1 of CPT with an excellent correlation coefficient (r = 0.9995). The limit of detection and limit of quantification were 7.31 x 10-6 e 2.43 x 10-5 mol l-1 of CPT, respectively. The proposed method was successfully applied to the determination of CPT in commercial brands of pharmaceuticals. No interferences were observed from the common excipients in the formulations. The results obtained by the proposed method were favorably compared with those given by the official reported method at 95 % confidence level.
Highlights
Captopril, 1 - [(2S)- 3 - mercapto -2 -methylpropionyl]-L-proline (Figure 1), (CPT) is an angiotensin-converting enzyme inhibitor, which reduces peripheral resistance end lowers blood pressure
In order to assure the quality of CPT containing pharmaceutical formulations, several methods have been developed for its determination, including batch fluorimetry [3], chemiluminescence [4 – 7], AAS [8, 9], high-performance liquid chromatography (HPLC) [10 – 17], GC [18], differential pulse polarography [19], amperometry [20 – 22], volumetric titration [23], potentiometric titration [24 – 28], capillary electropho
We report a novel, simple, rapid, cost-effective, precise, sensitive and accurate spectrophotometric method that is ideal for routine analysis of CPT in pharmaceuticals
Summary
1 - [(2S)- 3 - mercapto -2 -methylpropionyl]-L-proline (Figure 1), (CPT) is an angiotensin-converting enzyme inhibitor, which reduces peripheral resistance end lowers blood pressure. It is extensively used for the treatment of hypertension [1] and congestive failure [2]. In order to assure the quality of CPT containing pharmaceutical formulations, several methods have been developed for its determination, including batch fluorimetry [3], chemiluminescence [4 – 7], AAS [8, 9], high-performance liquid chromatography (HPLC) [10 – 17], GC [18], differential pulse polarography [19], amperometry [20 – 22], volumetric titration [23], potentiometric titration [24 – 28], capillary electropho-. Batch methods are generally time-consuming and laborious. Titrimetric method has suffered from a lack of specificity and sensitivity, under certain circumstances, such as the presence of unsaturated organic compounds
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