Abstract
A number of antiparkinsonian and miscellaneous drugs were examined for their ability to protect mice from physostigmine induced death and tremorine, oxotremorine and nicotine induced tremors. Typical antiparkinsonian drugs, such as centrally acting anticholinergics (hyoscine, atropine, benztropine, trihexyphenidyl, procyclidine, biperiden and ethopropazine) and antihistamines (promenhazine and diphenhydramine) were effective against physostigmine induced death, whereas other drugs, ineffective in parkinsonian therapy, were ineffective. The use of the physostigmine induced death method in preliminary screening for antiparkinsonian drugs in mice was more specific than either tre tremorine or oxotremorine tremor method.
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