Abstract

Introduction: The present study aimed to evaluate the potential utility of thrombosis in myocardial infarction (TIMI) risk index (TRI) for the prediction of stent thrombosis (ST) in ST elevation myocardial infarction (STEMI) patients who were treated with primary percutaneous coronary intervention ( pPCI ). Methods: This retrospective study was related to the clinical data of 1275 consecutive STEMI patients who underwent pPCI from January 2013 to January 2018. The TRI was calculated for each patient, and the following equation was used; TRI = heart rate x [age/10]2/systolic blood pressure. For the definition of ST, the criteria as proposed by the Academic Research Consortium were applied. Results: The incidence of ST was 3.2% (n=42 patients) in the study. The median value of the TRI was significantly elevated in patients with ST compared to those without ST (22 [17-32] vs. 16 [11-21], P<0.001, respectively). In a multivariate logistic regression analysis, the TRI was an independent predictor of ST (odds ratio [OR]: 1.061; 95% CI: 1.038-1.085; P<0.001). In a receiver operating characteristic curve analysis, the optimal value of the TRI for the prediction of ST was 25.8 with a sensitivity of 45.2% and a specificity of 86.4%. Conclusion: The present study finding has demonstrated that the TRI may be an independent predictor of ST in STEMI patients who were treated with pPCI . To the best of our knowledge, this is the first study in the literature in which the TRI and its relationship with ST was evaluated in STEMI patients treated with pPCI .

Highlights

  • The present study aimed to evaluate the potential utility of thrombosis in myocardial infarction (TIMI) risk index (TRI) for the prediction of stent thrombosis (ST) in ST elevation myocardial infarction (STEMI) patients who were treated with primary percutaneous coronary intervention

  • Thrombosis in myocardial infarction (TIMI) risk index (TRI) is a simple and easy risk score that has been shown to be useful for the prediction of short-and long-term mortality in patients who present with STEMI.[9,10,11]

  • A multivariate logistic regression analysis was used to determine independent predictors of ST using parameters found to be associated with ST in a univariate analysis

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Summary

Introduction

The present study aimed to evaluate the potential utility of thrombosis in myocardial infarction (TIMI) risk index (TRI) for the prediction of stent thrombosis (ST) in ST elevation myocardial infarction (STEMI) patients who were treated with primary percutaneous coronary intervention (pPCI). Thrombosis in myocardial infarction (TIMI) risk index (TRI) is a simple and easy risk score that has been shown to be useful for the prediction of short-and long-term mortality in patients who present with STEMI.[9,10,11] The TRI includes non-laboratory depending parameters -such as age, systolic blood pressure, and heart rate- all of TIMI risk index for stent thrombosis which can be obtained at the first medical contact. We aimed to evaluate the potential utility of TRI for the prediction of ST in STEMI patients who underwent pPCI

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