Abstract
We designed and realized for the first time an approach to indolizino[7,6-b]indoles. This approach is based on the Leuckart–Wallach reaction of 2-(2-oxoalkyl)indoles with formamide followed by Bischler–Napieralski cyclization producing γ-carbolines. The alkylation of 3-alkyl-γ-carbolines with phenacyl bromides followed by the treatment of the formed pyridinium salt with base produced the target aromatic tetracyclic system.
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