Abstract
A simple modification of the GE Tracerlab FX C Pro system which enabled performance of both solvent capture (loop method) and conventional solution phase [ 11C]methylation in the same module is described. By the quick setup and automated method, [ 11C]carfentanil and [ 11C]raclopride could be prepared in rapid succession without opening the hot cell. The radiochemical yields were over 40% and 30% (decay-corrected and based on [ 11C]methyl iodide) for [ 11C]carfentanil and [ 11C]raclopride, respectively. The radiochemical purities were greater than 95% and specific activities over 5 Ci/mmol for both tracers. The modification is extremely easy and can be utilized for multiple syntheses of other 11C-labeled radiopharmaceuticals in a fast and reliable manner.
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