Abstract
AbstractThe synthesis of α‐ureidopeptidomimetics employing a simple, mild and straight forward route starting from benzyloxy carbonyl (Cbz‐) protected amino acid esters in presence of 2‐Cl pyridine (2‐chloropyridine) and Tf2O (triflic anhydride) in one‐pot is described. The in situ generated isocyanate intermediates react with amino acid esters to yield the title compounds in good yields (89‐96%) and the protocol proved to be racemization free.
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