Abstract
The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng mL−1 and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%. The limits of detection and quantification were 15 ng mL−1 and 50 ng mL−1, respectively. Drug levels were determined satisfactorily in two patients. A simple and reliable method was developed, especially useful in children with heart failure under treatment with propafenone.
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