Abstract
A new method for the measurement of the concentration of gold in serum, blood, and urine is described. Gold is chelated by ammonium pyrrolidine dithiocarbamate, extracted from biologic fluids into methylisobutyl ketone, and the concentration is measured by atomic absorption spectroscopy. A linear relation is obtained between serum and urine concentrations, and absorption meter read-out values. The coefficients of variation of standard gold concentrations range from 1 to 16% in serum, and 1.3 to 9.2% in urine. Using a 95% confidence limit and logarithmic transforms, the variability of values at low concentrations in urine is small. There is no significant binding of gold to cellular blood elements. This method allows frequent and inexpensive determinations of gold concentrations in patients with rheumatoid arthritis on chrysotherapy.
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