Abstract
A simple and rapid method for the derivatisation of LCAA-CPG for the solid phase synthesis of oligonucleotides is described. The appropriately protected 2′-deoxynucleoside-3′-O-succinate 1 is reacted with an analogous amount of a bifunctional reagent, tolyene-2,4-diisocyanate in the presence of 4-dimethylaminopyridine to generate monoisocyanate II which, in the subsequent reaction with LCAA-CPG in the presence of N-ethyldiisopropylamine generated the fully functionalised support III with excellent nucleoside loadings.
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