Abstract
目的 评价含64μg/ml头孢噻肟的CHROMagar尿道菌定位琼脂在检测产超广谱β内酰胺酶(ESBLs)细菌中的作用.方法 以美国临床和实验室标准协会(CLSI)推荐的酶抑制剂增强试验检测产ESBLs菌株结果为标准,评价含头孢噻肟CHROMagar尿道菌定位琼脂在检测产ESBLs细菌的敏感度和特异度.菌株鉴定采用API条.结果 在上海华山医院临床分离的260株大肠埃希菌和287株肺炎克雷伯菌中,CLSI推荐的酶抑制剂增强试验检测产ESBLs菌株分别为175株、200株.含64μg/ml头孢噻肟CHROMagar尿道菌定位琼脂检测产ESBLs菌株分别为172株、197株.与CLSI推荐的酶抑制剂增强试验检测结果相比,含64μg/ml头孢噻肟CHROMagar尿道菌定位琼脂检测大肠埃希菌中产ESBLs菌株的敏感度、特异度和准确性分别为98.3%(172/175)、100%(85/85)和98.8%(257/260),肺炎克雷伯菌中产ESBLs菌株的敏感度、特异度和准确性分别为98.5%(197/200)、100%(87/87)和98.9%(284/287)结论 含64μg/ml头孢噻肟CHROMagar尿道菌定位琼脂在鉴定大肠埃希菌和肺炎克雷伯菌的同时即能检测是否为产ESBLs菌株,不失为一种简便快捷的方法,值得在临床微生物实验室推广应用。
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