A simple isolation of 211At using an anion-exchange spin column method

Abstract

This study demonstrated the availability of an anion-exchange spin column method for the isolation of astatine-211 (211At) from bismuth (Bi). 211At was isolated in medium-to-excellent recovery efficiencies when loading 211At with 8M HCl (75.3–79.1%), and 8M HNO3 (35.9–54.3%). The processing time of the optimized protocol was about 40 minutes. A neutralized eluent afforded an 211At-labeled phenylalanine derivative even in the absence of oxidant (radiochemical yield: 75.4%). These results indicate the anion-exchange spin column is useful for the isolation of 211At and the following synthesis of astatinated compounds, which is the first to isolate 211At with an anion-exchange method.