Abstract
Exploiting specific and sensitive techniques for tracking peroxynitrite (ONOO−) in the biological systems is of great significance to understand its diverse pathophysiology. Herein, we have constructed a simple, 4-hydroxynaphthalimide-derived two-photon fluorescent probe TPHQ for imaging ONOO− in live cells. Probe TPHQ with the recognition receptor of hydroquinone moiety exhibited excellent selectivity towards ONOO− over various bio-related analytes including H2O2 and OCl−. Additionally, probe TPHQ could rapidly monitor ONOO− with high sensitivity (DL = 16 nM). With probe TPHQ, the fluctuations of ONOO− levels in live cells were successfully tracked by the one-photon and two-photon fluorescence microscopy.
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