Abstract
In his recent paper, Dale (1985) proposed a new approach to the problem of the isoeffect doses in radiation therapy, for both fractionated and protracted irradiations. This approach resulted from the application of the linear quadratic dose–effect equation. With the incorporation of one additional parameter, μ, which relates to the rate of recovery of sublethal damage, he derived a more general formulation, as compared to the proposal of Barendsen (1982). This factor μ is related to the half-time of dose recovery (t 1/2) from the equation: and represents the time constant of repair, assuming first order exponential kinetics.
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