Abstract
By using easily accessible heterocyclic enamines, acetaldehyde (or formaldehyde) and primary amines as suitable precursors, a water-assisted three-component synthesis of new 3-oxothiazolo[3,2-c]pyridimines has been efficiently achieved in mild and semi-aqueous medium. All the cyclization reactions under optimized and catalyst-free conditions furnish the target compounds in 40–100% yields. Although cyclizations with arylamines in the presence of formaldehyde yield moderate to good yields, certain cyclizations involving aryl amines in the presence of acetaldehyde do not result in any product formation. Structural characterization of all the products were performed by means of FT-IR,1H and 13C NMR and HRMS analyses. Besides, some of the products demonstrated bacteriostatic effects in the antibacterial study conducted against S. aureus and S. epidermidis bacteria.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
