Abstract
A new type of polyoxyphenylpropeone fluorescent probe was designed by one pot method. In this article, through a simple synthetic route, a sensitive fluorescent probe for the detection of Fe3+ and Cu2+ in vitro was successfully synthesized. Interestingly, the fluorescence of this novel probe quenched significantly in the presence of Fe3+ and Cu2+. Ketone carbonyl group and oxygen atom form the natural coordination site of iron ion and copper ion. After the coordination with metal ion, the conjugated system of the compound is broken, resulting in fluorescence quenching. At the same time, transmission electron microscope (TEM) were conducted to found its morphology property and the result shows that the polymer is stacked in layers in the images. The results of cell imaging confirmed that the polymer probe possessed favorable biocompatibility. The in vivo experiment of mice also gained the same conclusion with high penetration and fluorescence intensity. Due to the convenience of synthesis and superior recognition performance, this fluorescent probe has great potential in the study of accumulation and transformation of heavy metal ions in vivo and clinical detection of Fe3+ and Cu2+.
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