Abstract
A series of substituted Hantzsch 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of analytical and spectral data such as FT-IR and 1H-NMR. The advantages of this system are one-step procedure, high yields of the products and the ability to carry out large-scale reactions
Highlights
Multicomponent reactions (MCRs) are onepot processes that combine three or more substrates simultaneously (Guillena, et al, 2007)
A series of substituted Hantzsch 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of analytical and spectral data such as FT-IR and 1H-NMR
Dihydropyridine (DHP) is a molecule based up on pyridine, and the parent of a class of molecules that have been semi-saturated with two substituent’s replacing one double bond. They are well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension compared with certain other L-type calcium channel blockers [For example those of the phenyl alkylamine class such as verpamil] which have significant action at the heart, they are relatively vascular selective action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure
Summary
Multicomponent reactions (MCRs) are onepot processes that combine three or more substrates simultaneously (Guillena, et al, 2007). Dihydropyridine (DHP) is a molecule based up on pyridine, and the parent of a class of molecules that have been semi-saturated with two substituent’s replacing one double bond They are well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension compared with certain other L-type calcium channel blockers [For example those of the phenyl alkylamine class such as verpamil] which have significant action at the heart, they are relatively vascular selective action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. Some of the representative compounds of this class possess acaricidal, insecticidal, bactericidal and herbicidal activities (Kawase et al, 2002) It has been recognized as vital drugs in the treatment of angina and hypertension (Janis and Triggle, 1983; Boecker and Guengerich, 1986). We decided to synthesize new derivatives of 1,4-dihydropyridines and provide a clean and easy work-up
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