Abstract
A simple, rapid, and reliable HPTLC method has been established for determination of pantoprazole sodium sesquihydrate in tablets. Identification and determination were performed on aluminum-backed silica gel 60 F 254 TLC plates previously washed with methanol. The mobile phase was methanol-water-ammonium acetate, 4 + 1 + 0.5 ( v/v ). Calibration plots were established showing the dependence of response (peak area) on the amount chromatographed. The spots were scanned at λ = 290 nm. The suitability of this HPTLC method for quantitative determination of compound was proved by validation in accordance with the requirements of pharmaceutical regulatory standards. The method was used for determination of the compound in commercial pharmaceutical dosage forms. The method is simple, reproducible and accurate and is a more effective option than other chromatographic techniques in routine quality control.
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