Abstract
A simple and direct method of labelling brain norepinephrine stores, via injection into the lateral ventricle is described. H 3-norepinephrine introduced by this procedure was found to be distributed evenly in both sides of the brain. The accumulation of H 3-norepinephrine in various brain regions parallels that of endogenous levels of norepinephrine and the amine is selectively localized in the “nerve endings”. The disappearance of H 3-norepinephrine administered by the direct injection technique and its modification by drugs are similar to that of material introduced by stereotaxic procedures.
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