Abstract
An efficient synthetic method was developed for the preparation of 1‐octacosanol (C28‐alcohol) from commercially available lipid‐based intermediates namely sebacic acid (decanedioic acid) and stearyl alcohol. The key step in the synthesis is the preparation of tert‐butyl dimethyl octacos‐10‐enyloxy silane from 10‐tert‐butyl dimethyl silanyloxy decanal and octadecyl triphenylphosphonium bromide salt employing Witting reaction. This product on simultaneous hydrogenation of double bond and deprotection of tert‐butyldimethylsilyl protecting group in a single step on treatment with Pd/C and H2 in methanol at ambient temperature resulted octacosanol in 95% yields. The products were characterised by IR, 1H NMR, and GC–MS analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
