A simple and efficient procedure for diazotization-iodination of aromatic amines in aqueous pastes by the action of sodium nitrite and sodium hydrogen sulfate

Abstract

One of the most widely used methods of synthesis of aromatic iodides is based on diazotization–iodina-tion of aromatic amines. The diazotization is generally carried out using accessible sodium nitrite in strongly acidic medium at reduced temperature [1–5]. Alter-native procedures involve more expensive alkyl nitrites as diazotizing agents in the presence of diiodomethane or other sources of iodine [6, 7]. We previously pro-posed simple procedures for diazotization–iodination with sodium nitrite at room temperature in weakly acidic media created by