Abstract
Indole-3-sulfonyl carbamate served as a key intermediate for the synthesis of a HPK1 inhibitor, bearing a primary sulfonamide group. A simple and efficient synthesis of this key indole-3-sufonyl carbamate was developed using the readily available Burgess reagent and Lewis acids. A systematic evaluation of a variety of Lewis acids with Burgess reagent to optimize the synthetic yield of indole-3-sulfonyl carbamate is reported in this paper.
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