Abstract
To explore the epidemic mode of COVID-19, we made an epidemiological investigation, set up hypothetical models, and compared them with hepatitis A virus (HAV) age-specific epidemic characteristic. In the epidemiological investigation, we reported the first familial COVID-19 silent infection in the world. A 19-year-old healthy female COVID-19 virus carrier without any symptoms caused two mild and one severe pneumonia. In hypothetical models, the silent infection rate ranges from 60% to 80% based on 3 sources: China mainland, evacuation of 4 nationals, and the ship “Diamond Princess,” respectively. In comparison with HAV, COVID-19 shows the same infection mode in children (aged 0–9 years), but significant difference in young adults (aged 10–44 years) and the elderly (aged 45 years or older). Therefore, we prejudged that COVID-19 is a silent infection pandemic mainly in young adults but threatens the elderly.
Highlights
An Asymptomatic COVID-19 Carrier Caused a Family Cluster with One Severe and Two Mild Pneumonia e index is a 19-year-old girl who studied in a university in Wuhan and returned to her hometown Anyang, in Henan Province, on January 10, 2020
By conducting an epidemiological investigation, exploring the hypothetical models, and comparing the age-specific epidemic characteristics of COVID-19 with those of hepatitis A virus (HAV), we explored the mode of COVID-19 transmission and spread
On January 26, 2020, she was isolated without any symptoms and was negative for both chest X-ray examination and COVID-19 nucleic acid test (NAT) (Sansure Biotech, Changsha, China) using throat and nose swab samples. e girl had no diseases and drug history recorded recently. e Anyang Municipal Center for Disease Control and Prevention (CDC) tested the Canadian Journal of Infectious Diseases and Medical Microbiology girl again on January 28, 2020, and both throat and nose swab samples were positive for COVID-19 NAT
Summary
An Asymptomatic COVID-19 Carrier Caused a Family Cluster with One Severe and Two Mild Pneumonia e index is a 19-year-old girl who studied in a university in Wuhan and returned to her hometown Anyang, in Henan Province, on January 10, 2020 She had no fever, sore throat, or any respiratory symptoms for 60 days till March 9, the end of our follow-up. Patient 2, male, aged 45, the girl’s father, had a fever and respiratory symptoms on January 23 and was isolated for treatment in the Anyang People’s Hospital on January 26 He was diagnosed as a suspected case of pneumonia with COVID-19 infection by an expert group consultation. After isolation for treatment and consultation by an expert group, the woman was diagnosed as a suspected case of pneumonia with COVID-19 infection Her throat swab and sputum samples were positive for COVID-19 NAT on January 26.
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