Abstract
Background: Hepatocellular carcinoma (HCC) is, by far, the most common liver malignancy. The risk factors for the development of HCC are numerous with liver cirrhosis, chronic hepatitis B and C viral infections and alcohol abuse on top of the list. Several studies were devoted to evaluate the complex radiological appearance of HCC and its correlation with histopathologic grade/stage as well as possible mimickers of HCC, all of which have a significant impact on diagnosis and management of patients with HCC. Objectives: Evaluation of the radiological findings of HCC and its correlation with histopathologic grade/stage as well as mimickers of HCC. Methods: This is a review article of some of the existing literature regarding radiological findings and histopathologic diagnosis of progressed hepatocellular carcinoma. Conclusion: Imaging findings of progressed HCCs are complex and different from the standard findings of welldifferentiated HCCs. Evaluation of enhancement and washout patterns, as well as the possibility of the presence of microvascular invasion, should be undertaken by the reporting radiologist and delivered comprehensively to the treating multidisciplinary team for proper management.
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