Abstract
This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates “T cell help” and on dendritic cells helps to program CD8 T cell responses. I discuss some things that we got right during the path of discovery and some things we missed. Immunotherapies that block or stimulate the CD40 pathway hold great promise for treatment of autoimmune diseases and cancers.
Highlights
Reviewed by: Bruce David Mazer, Montreal Children’s Hospital, Canada Kendall A
Clark, 750 Republican Street, Room E343, Seattle, WA, USA e-mail: eaclark@uw.edu. This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates “T cell help” and on dendritic cells helps to program CD8 T cell responses
As had been the case for HLA nomenclature, a neutral nomenclature was needed for human differentiation antigens, particular since markers like CD4 were called different names-T4, OKT4, Leu3, etc., depending on the company that was hawking the monoclonal antibodies (mAbs) for sale
Summary
Reviewed by: Bruce David Mazer, Montreal Children’s Hospital, Canada Kendall A. During the late 1970s, a number of immunology labs started using the new hybridoma technology to establish monoclonal antibodies (mAbs) and define receptors expressed at different stages of hematopoietic cell differentiation.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
