Abstract
The goals of time-resolved macromolecular crystallography are to extract the molecular structures of the reaction intermediates and the reaction dynamics from time-resolved X-ray data alone. To develop the techniques of time-resolved crystallography, biomolecules with special properties are required. The Photoactive Yellow Protein is the most sparkling of these.
Highlights
The goals of time-resolved macromolecular crystallography are to extract the molecular structures of the reaction intermediates and the reaction dynamics from time-resolved X-ray data alone
Photoactive Yellow Protein (PYP) is a structural archetype of the PAS (Per-ARNT-Sim) domain superfamily4 that is responsible for a vast range of stimuli ranging from light sensing to small ligands
It was discovered that upon blue light absorption, PYP displays a photocycle8 that is based on the trans to cis isomerization of the central chromophore para-hydroxy-cinnamic acid called p-coumaric acid
Summary
The goals of time-resolved macromolecular crystallography are to extract the molecular structures of the reaction intermediates and the reaction dynamics from time-resolved X-ray data alone.
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