Abstract
c-Myb is an important regulator of haematopoiesis expressed principally in haematopoietic stem cells and progenitors (HSC/HPC). Aberrant expression of c-Myb has been linked to the development of several types of leukaemia including Acute Lymphoblastic Leukaemia (ALL) and Acute Myeloid Leukaemia (AML). Previously, we demonstrated differential regulation of the c-myb gene in murine myeloid leukaemic cells compared to normal HSC. This differential pattern of regulation was shown to be mediated by HoxA9 and its cofactor Meis1 together with the proteins from the Pbx family, Pbx1 and Pbx2, and involved a shift in promoter usage from the conventional (P1) in normal HSC to a second promoter (P2) upstream of exon 2 in leukaemic cells.
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