Abstract
SummaryA 48 year old female underwent an uneventful laparoscopic cholecystectomy under general anaesthesia in the day surgery unit. She received 4mg ondansetron intravenously before emergence from anaesthesia. Thirty minutes later, in the recovery room, she developed a severe dystonic reaction, which was attributed to ondansetron. She showed improvement with 20mg procyclidine and 2 mg midazolam given intravenously and was discharged home without any neurological sequelae on the third day. This reaction caused significant distress to the patient, increased hospital stay and associated expense. Measures were taken to prevent recurrence; the reaction was highlighted on the electronic patient record system and the patient's GP informed of this and other potential triggering agents.
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