Abstract
Mitochondria, microsomes and cell sap from embryonic chick liver have been tested with sera produced against the homologous fractions from adult liver. Since the earliest stages of development considered, each one of the three subcellular fractions was able to give rise to a number of precipitation lines when reacting with the homologous adult antiserum. In the course of development the pattern of precipitation lines progressively approaches that of the adult. However, the microsomal fraction from embryonic liver, which is known to contain a large amount of free ribonucleoprotein particles, does not give rise to any reaction like that obtained with adult liver ribosomes. Chemical analyses of the embryonic microsomes from different stages of development have demonstrated a high RNA protein ratio in the earliest stages which decreases until the 18th day of incubation when values identical to those of the adult are reached.
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