Abstract
Since Kimura’s neutral theory has been accepted by biologists for the mechanism of evolution at the molecular level, most methods for analyzing molecular evolution are developed based on this theory. These studies, however, aim to detect positive selection, and do not study how neutral evolution and positive selection behave as time goes on. In this study, we develop a new method to detect when the neutral and adaptive evolution occur in the process of within-host viral evolution, and to reconstruct a longitudinal phylogenetic tree using sequential molecular sequences. We applied the method to a data set of the V3 region of HIV-1 envelope gene and carried out a detailed analysis of viral evolution.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
