A Sensitive Voltammetric Sensor for Improved Simultaneous Determination of Moxifloxacin Hydrochloride and Paracetamol

Abstract

An electrochemical sensor was prepared using a platinum (Pt) electrode modified with a binary layer of poly(1,5-diaminonaphthalene) (p-1,5-DAN) and platinum nanoparticles (PtNPs). The obtained sensor was investigated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), square wave voltammetry (SWV), and electroactive surface area measurements (EASA). The PtNPs/p-1,5-DAN/Pt electrode was applied for individual and simultaneous determination of Paracetamol (PCT) and moxifloxacin hydrochloride (MFH) in aqueous solutions of Britton–Robinson buffer (BRB). Under optimized conditions, the PtNPs/p-1,5-DAN/Pt electrode exhibited excellent sensing ability toward the oxidation of PCT and MFH with linear responses with ranges of 1–1000 μM and 10–1000 μM and detection limits of 0.09 μM and 0.10 μM, respectively. PtNPs/p-1,5-DAN/Pt exhibits good repeatability, reproducibility, and acceptable stability and was found to be applicablefor simultaneous determination of PCT and MFH in pharmaceutical formulations and spiked biological fluids.