Abstract
ABSTRACTA chemically modified sensor based on the synergistic effect of graphene and polyaniline for electrochemical sensing of calcium antagonist lercanidipine (LCP) has been developed. Scanning electron microscopy, electrochemical impedance spectroscopy, square‐wave voltammetry, and cyclic voltammetry were utilized to characterize the morphology and electroanalytical performance of the fabricated sensor. Under optimized conditions, reduction peak current was linear over the wide concentration range from 5 to 125 ng mL−1 with correlation coefficient of 0.9998. The limit of detection and the limit of quantification were found to be 1.94 and 5.89 ng mL−1. The developed sensor also exhibited good reproducibility and long‐term stability. In addition, the proposed method was successfully applied to the determination of LCP in pharmaceutical formulation which is proved by recovery studies. Graphene–polyaniline composites are expected to be promising material for biosensing applications because of the ease of fabrication, excellent electrochemical performance, and high electroactive surface area. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40959.
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