Abstract
A simple, accurate and highly sensitive spectrophotometric method for the determination of ritodrine hydrochloride (RTH), pentazocine hydrochloride (PZH), isoxsuprine hydrochloride (ISH) and amoxicillin (AMX) is described. The method is based on the oxidation of the studied drugs by a known excess of chloramine – T (CAT) in hydrochloric acid medium and subsequent determination of the unreacted oxidant by reacting it with iodide in the same acid medium liberates iodine, which subsequently react with starch to form a stable starch-iodine complex. The reacted oxidant corresponds to the drug content. The coloured complex exhibits a maximum absorption at 590 nm. The apparent molar absorptivity values and Sandell’s sensitivity values are in the range 6.96x104- 1.43x105L mol–1cm–1and 2.45-4.30 ng cm–2, respectively. The method was successfully applied to the studied drugs in their dosage forms. The results are reproducible within ±1% and compare favorably with those of official methods of British Pharmacopoeia and the United States Pharmacopoeia.
Highlights
Ritodrine hydrochloride (RTH), chemically 1-(4-hydroxy phenyl)-2-[2-(4- hydroxy phenyl) ethyl amino] propanol, is a β2- adrenergic agonist used to arrest preterm delivery in pregnant woman[1,2]
A highly sensitive indirect spectrophotometric determination of cited drugs with chloramine-T-iodine and starch is described, and the proposed method has been employed to the determination of studied drugs in pure and in dosage forms
India), ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) (Duphar-Interfran Ltd., India) were prepared by dissolving the requisite amount of the samples in distilled water, working solutions prepared as required by dilution
Summary
Ritodrine hydrochloride (RTH), chemically 1-(4-hydroxy phenyl)-2-[2-(4- hydroxy phenyl) ethyl amino] propanol, is a β2- adrenergic agonist used to arrest preterm delivery in pregnant woman[1,2]. For the determination of studied drugs, other methods include HPLC,[12,13,14] titrimetric[15] and fluorimetric[16,17] are reported in the literature Some of these methods required expensive reagents, less sensitive, poor selective, time consuming and tedious experimental procedures. Chloramine-T (≅ 0.01 mol L–1) was prepared by dissolving 0.28 g of CAT in 100 mL of distilled water and standardized iodometrically This solution was diluted subsequently to get 100 μg mL-1 solution. Aqueous solutions of pentazocine hydrochloride (PZH) (Sigma Laboratories Pvt. Ltd., Mumbai), amoxicillin (AMX) (Cadila Health Care Ltd. India), ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) (Duphar-Interfran Ltd., India) were prepared by dissolving the requisite amount of the samples in distilled water, working solutions prepared as required by dilution
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