A Sensitive Electrochemical Sensor Based on Sonogel-Carbon Material Enriched with Gold Nanoparticles for Melatonin Determination.

Cecilia Lete,Stelian Lupu,Sorina-Alexandra Leau,Laura Cubillana-Aguilera,Adina Elena Stanciu,David López-Iglesias,Juan José García-Guzmán,José Maria Palacios-Santander,Mariana Marin

doi:10.3390/s22010120

Abstract

In this work, the development of an electrochemical sensor for melatonin determination is presented. The sensor was based on Sonogel-Carbon electrode material (SNGCE) and Au nanoparticles (AuNPs). The low-cost and environmentally friendly SNGCE material was prepared by the ultrasound-assisted sonogel method. AuNPs were prepared by a chemical route and narrow size distribution was obtained. The electrochemical characterization of the SNGCE/AuNP sensor was carried out by cyclic voltammetry in the presence of a redox probe. The analytical performance of the SNGCE/AuNP sensor in terms of linear response range, repeatability, selectivity, and limit of detection was investigated. The optimized SNGCE/AuNP sensor displayed a low detection limit of 8.4 nM melatonin in synthetic samples assessed by means of the amperometry technique. The potential use of the proposed sensor in real sample analysis and the anti-matrix capability were assessed by a recovery study of melatonin detection in human peripheral blood serum with good accuracy.

Highlights

Introduction published maps and institutional affilMelatonin (N-acetyl-5-methoxytryptamine, MEL) belongs to the organic compound class known as 3-alkylindoles
The size of synthesized the Au nanoparticles (AuNPs) is a key were pointinvestigated for their applications because it tigated
The preparation and characterization of various sensing materials based on SonogelCarbon and Au nanoparticles were carried out

Summary

Introduction

Introduction published maps and institutional affilMelatonin (N-acetyl-5-methoxytryptamine, MEL) belongs to the organic compound class known as 3-alkylindoles. Due to its antioxidant capacity, MEL helps to regulate the sleep–wake cycle and the production of other hormones [1,2,3]. It has been used in the treatment of several gastrointestinal diseases such as irritable bowel system and ulcerative colitis as well as in neurodegenerative diseases such as Alzheimer’s and Parkinson’s [4]. Due to its important roles in numerous pathological, physiological, and biological processes, unsuitable levels of melatonin in our bodies can lead to different diseases.

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