A Sensitive and Selective Non-Enzymatic Glucose Sensor based on AuNPs/CuO NWs-MoS2 Modified Electrode

Abstract

In recent years, copper-based nanomaterials have been widely used in the study of glucose sensors because of its high sensitivity. In this work, a sensitive and selective electrochemical enzyme-free glucose sensor was successfully constructed using a composite of copper oxide nanowires (CuO NWs), molybdenum disulfide (MoS2) and gold nanoparticle (AuNPs). This composite was systematically characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The sensor performance and interface property of the Au electrode modified by NF/AuNPs/CuO-MoS2 were measured by cyclic voltammetry (CV) and chronoamperometric measurements(i-t). Under optimal condition, the proposed sensor shows sensitivity value of 872.71 μA cm−2 mM−1 for glucose, with detection range from 0.5 μM to 5.67 mΜ and detection limit of 0.5 μM. The study also confirms satisfactory selectivity, reproducibility, and stability of the constructed sensor. This NF/AuNPs/CuO NWs-MoS2 sensor performance toward normal human serum spiked with glucose is determined with RSD less than 4.71%, indicating superior potential for the practical quantitative analysis of glucose in serum samples.