A semi-supervised classification RBM with an improved fMRI representation algorithm

Abstract

Background and objectiveTraining an effective and robust supervised learning classifier is not easy due to the limitations of acquiring and labeling considerable human functional magnetic resonance imaging (fMRI) data. Semi-supervised learning uses unlabeled data for feature learning and combines them into labeled data to build better classification models. MethodsSince no premises or assumptions are required, a restricted Boltzmann machine (RBM) is suitable for learning data representation of neuroimages. In our study, an improved fMRI representation algorithm with a hybrid L1/L2 regularization method (HRBM) was proposed to optimize the original model for sparsity. Different from common semi-supervised classification models that treat feature learning and classification as two separate training steps, we then constructed a new semi-supervised classification RBM based on a joint training algorithm with HRBM, named Semi-HRBM. This joint training algorithm jointly trains the objective function of feature learning and classification process, so that the learned features can effectively represent the original fMRI data and adapt to the classification tasks. ResultsThis study uses fMRI data to identify categories of visual stimuli. In the fMRI data classification task under four visual stimuli (house, face, car, and cat), our HRBM has satisfactory feature representation capabilities and better performance for multiple classification tasks. Taking the supervised RBM (sup-RBM) as an example, our Semi-HRBM classification model improves the average accuracy of the four-classification task by 7.68%, and improves the average F1 score of each visual stimulus task by 8.90%. In addition, the generalization ability of the model was also improved. ConclusionThis research might contribute to enrich solutions for insufficiently labeled neuroimaging samples, which could help to identify complex brain states under different stimuli or tasks.